- Posted by Vinay Yadav
- On July 12, 2021
- 0 Comments
Antineoplastic properties of green tea (review)
Summary. The results of epidemiological, experimental and clinical studies of the antitumor properties of green tea and its catechins published in the scientific literature are analyzed. The study of cellular and molecular mechanisms of action shows that green tea catechins are able to inhibit the proliferation and invasiveness of tumor cells, inhibit neoangiogenesis, reduce oxidative damage, and induce atoptosis, which allows these compounds to be classified as multitarget agents.
It has been suggested that green tea and its catechins may become the basis for the development of new anticancer drugs.
Key words: Green tea, catechins, antitumor activity, mechanisms of action.
Antitumor properties of green tea (review)
D.B. Korman (Institute of biochemical physics Russian Acad.Sci)
Resume. Results of epidemiological, experimental and clinical study of green tea and its catechins are discussed. Investigations of cellular and molecular mechanisms of antitumor action of green tea shows that catechins of green tea are able to inhibit proliferation and invasion of tumor cells, inhibit neoangiogenesis, diminish oxidative damages and induce apoptosis.
Catechins of green tea may be considered as multitarget agents. It is proposed that green tea and its catechins may become a basis for development of new antitumor drugs.
Key words: Green tea, cathechins, antitumor activity, mechanisms of action.
The use by patients with chronic diseases, including cancer patients, methods of treatment that differ from those used by official medicine is becoming more widespread throughout the world.
These methods are collectively referred to as “alternative therapy”, which refers to a variety of therapeutic modalities that are not included in the treatment methods approved and recommended for medical use by special regulatory authorities operating in each country. To test and study alternative methods in many countries, special scientific centers have been created (for example, in the USA in 1992 by the decision of the Congress, the National Center for Alternative Medicine was formed at the National Institute of Health), scientific journals are published, monographs are published, and congresses are held. It is estimated that the Google search engine finds over 3.4 million sites on the Internet with information on alternative therapies .
In alternative cancer therapy, the use of green tea is often recommended, and not only as a means of symptomatic therapy, given the well-studied detoxifying, tonic and immunomodulatory properties of this drink, but also as an https://ru.life-hacks.fun/page-kak-stat-bolee-sotsial-nym-esli-vy-introvert agent with antitumor activity.
The interest in green tea as an antineoplastic agent is due to a number of circumstances. First, it is known that in the homeland of tea – in China – this plant has been used for many centuries not only for making a drink, but also for medicinal purposes to treat various diseases, including cancer.
Secondly, in 1980-1990. a number of epidemiological studies have been carried out in the countries of Southeast Asia, the results of which indicated a certain relationship between the consumption of green tea and cancer incidence. The third factor should be considered the wide recognition of the important role of oxidative stress, free radical oxidation in the pathogenesis of many diseases, including malignant tumors, and the consequent recognition of antioxidants as potential drugs for the prevention and treatment of various diseases. Green tea is a rich source of highly active polyphenolic antioxidants.
These factors stimulated the study of green tea extract and its individual components as one of the components of alternative therapy, including antitumor therapy. In these studies, especially intensively developing in the last decade, several directions can be distinguished.
Epidemiological studies are still ongoing, which can be divided into 2 groups. The first group consists of case-control studies designed to retrospectively evaluate the results of green tea consumption. Another group should include prospective studies in which a sufficiently large group of healthy people are interviewed about the use of green tea (amount, frequency, duration, etc.), then they are monitored for a certain time, during which all cases of cancer are recorded and the relationship is assessed between the consumption of green tea and the appearance of tumors.
It should be emphasized that this kind of research is still carried out mainly in countries with a traditionally high consumption of this drink (China, Japan). In the United States and European countries, where green tea is rarely used, large-scale epidemiological studies are unrealistic. In the US, green tea is